Engineering Antibodies 2012
May 2 - 3, 2012
Boston MA , USA
ANTIBODY DISCOVERY STRATEGIES AND TOOLS
Multidimensional Glycan Arrays for Selection and Characterization of Carbohydrate-Binding Antibodies
Jeffrey C. Gildersleeve, Ph.D., Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute-Frederick
Carbohydrate-binding antibodies are used extensively for basic research and have clinical applications as therapeutic agents and diagnostics. We have developed a carbohydrate microarray or “glycan array” containing hundreds of carbohydrate antigens immobilized on a glass microscope slide. To enhance diversity, the array contains variations in both carbohydrate structure and presentation. The array provides a high-throughput tool for evaluating antibody-antigen interactions.
Elicitation of Structure-Specific Antibodies by Epitope Scaffolds: Application to HIV-1 Vaccine Design
Tools for the Evaluation of Disulfide-Mediated Heterogeneity Characteristic to IgG2 Monoclonal Antibodies
Multidimensional Glycan Arrays for Selection and Characterization of Carbohydrate-Binding Antibodies
Jeffrey C. Gildersleeve, Ph.D., Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute-Frederick
Carbohydrate-binding antibodies are used extensively for basic research and have clinical applications as therapeutic agents and diagnostics. We have developed a carbohydrate microarray or “glycan array” containing hundreds of carbohydrate antigens immobilized on a glass microscope slide. To enhance diversity, the array contains variations in both carbohydrate structure and presentation. The array provides a high-throughput tool for evaluating antibody-antigen interactions.
Elicitation of Structure-Specific Antibodies by Epitope Scaffolds: Application to HIV-1 Vaccine Design
Tools for the Evaluation of Disulfide-Mediated Heterogeneity Characteristic to IgG2 Monoclonal Antibodies
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