Innovations in Drug Formulation and Delivery 2015

Developers of both small- and large-molecule therapeutics urgently need to overcome drug formulation and delivery challenges in order to improve bioavailability and therapeutic performance. Small molecule drugs are challenged by poor solubility, and while enabled formulations can help with this, they often encounter stability hurdles of their own. Intravenous delivery of biologics sets limits on patient adherence and market success, so the next generation of delivery challenges will focus on subcutaneous and oral routes to broaden product pipelines and lengthen life cycles.